NKG2D inhibitor 4e

Chemical Structure : NKG2D inhibitor 4e

Catalog No.: PC-21268Not For Human Use, Lab Use Only.

NKG2D inhibitor 4e is a small-molecule protein-protein interaction inhibitor for NKG2D with IC50 of 2.2 uM, disrupts the interaction between NKG2D and multiple protein ligands through allosteric modulation of the NKG2D receptor dimer/ligand interface.

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Biological Activity

NKG2D inhibitor 4e is a small-molecule protein-protein interaction inhibitor for NKG2D with IC50 of 0.1 uM, disrupts the interaction between NKG2D and multiple protein ligands through allosteric modulation of the NKG2D receptor dimer/ligand interface.

Physicochemical Properties

M.Wt	455.48
Formula	C25H24F3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-(dimethylamino)-1-(3,5-dimethylphenyl)-2-oxoethyl)-4-(4-(trifluoromethyl)phenyl)nicotinamide

References

1. Thompson AA, et al. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2216342120.

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