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NKY80

Chemical Structure : NKY80

CAS No.: 299442-43-6

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NKY80 (NKY 80, NKY-80)

Catalog No.: PC-60667Not For Human Use, Lab Use Only.

A potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.

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25 mg $158 In stock
50 mg $258 In stock
100 mg $428 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NKY80 is a potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.
NKY80 displays little to no activity for other AC isoforms (IC50>100 uM).
NKY80 blocks both BAPTA-AM-stimulated cAMP formation and renin release in primary cultures of juxtaglomerular cells.

Physicochemical Properties

M.Wt 229.239
Formula C12H11N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone

References

1. Onda T, et al. J Biol Chem. 2001 Dec 21;276(51):47785-93.

2. Ortiz-Capisano MC, et al. Hypertension. 2007 Mar;49(3):618-24.

3. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.

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