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Chemical Structure : NKY80
CAS No.: 299442-43-6
Catalog No.: PC-60667Not For Human Use, Lab Use Only.
A potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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NKY80 is a potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.
NKY80 displays little to no activity for other AC isoforms (IC50>100 uM).
NKY80 blocks both BAPTA-AM-stimulated cAMP formation and renin release in primary cultures of juxtaglomerular cells.
| M.Wt | 229.239 | |
| Formula | C12H11N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone |
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1. Onda T, et al. J Biol Chem. 2001 Dec 21;276(51):47785-93.
2. Ortiz-Capisano MC, et al. Hypertension. 2007 Mar;49(3):618-24.
3. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.
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