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Chemical Structure : NMD670
Catalog No.: PC-22007Not For Human Use, Lab Use Only.
NMD670 (NMD-670) is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).
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NMD670 (NMD-670) is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).
NMD670 shows no effect on Gm in a Cl− free experimental solution.
NMD670 (20 mg/kg) enhances neuromuscular transmission and restores muscle function in experimental autoimmune myasthenia gravis (MG) rats.
NMD670 (20 mg/kg) restores muscle force and motor performance in rat models of MG.
NMD670 improves running performance in a passive immunization MG rat model.
| M.Wt | 312.12 | |
| Formula | C12H10BrNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martin Skov, et al. Sci Transl Med. 2024 Mar 20;16(739):eadk9109.
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