NMS-P645 |CAS:1482518-95-5 Probechem Biochemicals

Chemical Structure : NMS-P645

NMS-P645 (NMS P645)

Catalog No.: PC-63141Not For Human Use, Lab Use Only.

NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.

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Biological Activity

NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.
NMS-P645 exhibits excellent selectivity against a large panel of kinases.
NMS-P645 reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments.
NMS-P645 induces a significant anti-proliferative response in PCa cells combined with GDC-0941.

Physicochemical Properties

M.Wt	512.095
Formula	C28H38ClN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((S)-7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)-N-((S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl)acetamide

References

1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80.

2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145.

NMS-P645 (NMS P645)

Biological Activity

Physicochemical Properties

References

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