NMS-P953

Chemical Structure : NMS-P953

Catalog No.: PC-24735Not For Human Use, Lab Use Only.

NMS-P953 is a potent and selective JAK2 inhibitor with IC50 of 8 nM, displays 18-, 4- and 18-fold selective over JAK1, JAK3 and TYK2 respectively.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

NMS-P953 is a potent and selective JAK2 inhibitor with IC50 of 8 nM, displays 18-, 4- and 18-fold selective over JAK1, JAK3 and TYK2 respectively.
NMS-P953 exhibits good potency in SET-2 antiproliferative assay with IC50 of 0.48 uM.
NMS-P953 displays significant tumour growth inhibition in SET-2 xenograft tumour model.

Physicochemical Properties

M.Wt	381.74
Formula	C16H11ClF3N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-

References

1. Brasca MG, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4998-5012.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

NMS-P953

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.