Chemical Structure : NN-01-195
CAS No.:
NN-01-195
Catalog No.: PC-26261Not For Human Use, Lab Use Only.
NN-01-195 is a chimeric small molecule conjugate of HSP90 and AURKA inhibitor, tightly binds and inhibits both AURKA and HSP90 with IC50 of 3.1 nM and 8.1 nM in biochemical assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NN-01-195 is a chimeric small molecule conjugate of HSP90 and AURKA inhibitor, tightly binds and inhibits both AURKA and HSP90 with IC50 of 3.1 nM and 8.1 nM in biochemical assays.
NN-01-195 combines an AURKA inhibitor related to TAS-119/VIC-1911 with an HSP90-binding moiety related to SNX2112.
NN-01-195 causes mitotic arrest and spindle abnormalities and a profile of signaling changes that closely resembles that of an AURKA inhibitor.
NN-01-195 reduces cell viability and promotes mitotic abnormalities.
NN-01-195 elevates apoptosis and reduces cell viability for human papillomavirus–negative HNSCC (FaDu, Detroit 562, and Cal27), NSCLC (H1975, PC9), and melanoma (WM3000, WM33451) models with IC50 of 0.27-2.98 uM.
NN-01-195 (10 mg/kg, IP) is highly effective at controlling xenograft tumor volume in FaDu cells xenografted onto NSG mice.
Physicochemical Properties
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M.Wt
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1128.07
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Formula
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C56H60Cl2F4N12O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(6-(4-(4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)phenyl)piperazin-1-yl)-6-oxohexyl)-1-(2,3-dichlorobenzoyl)-4-((5-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)methyl)piperidine-4-carboxamide
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References
1. Nguyen TT, et al. Mol Cancer Ther. 2026 Jan 23. doi: 10.1158/1535-7163.MCT-25-0857.
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