NOX4 inhibitor 18

Chemical Structure : NOX4 inhibitor 18

Catalog No.: PC-27679Not For Human Use, Lab Use Only.

NOX4 inhibitor 18 is a first-in-class homolog-selective, covalent NOX4 inhibitor with IC50 of 3.1 uM, IC50 app of 0.42 uM for NOX4 dehydrogenase domain, show no activity against NOX1,2,5 (IC50>100 uM).

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Biological Activity

Physicochemical Properties

M.Wt	349.35
Formula	C17H15N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(((3-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)amino)methyl)benzyl)-1H-pyrrole-2,5-dione

References

1. Castelôa M, et al. Biomed Pharmacother. 2026 Aug 14;203:119844.

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NOX4 inhibitor 18

Biological Activity

Physicochemical Properties

References

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