NP-1815-PX | P2X4 antagonist | Probechem Biochemicals

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Chemical Structure : NP-1815-PX

NP-1815-PX (P2X4 antagonist)

Catalog No.: PC-22525Not For Human Use, Lab Use Only.

NP-1815-PX is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NP-1815-PX is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.
NP-1815-PX has no effect on ATP-induced [Ca2+]i increase in hP2X7R- and rP2X3R-1321N1 cells, with IC50 of >30 μM for hP2X1R, rat (r) P2X3R, hP2X2/3R and hP2X7R, and 7.3 μM for hP2X2R.
NP-1815-PX inhibits ATP-mediated responses in primary cultured microglial cells.
NP-1815-PX (10 and 30 pmol/mouse) exhibits an inhibitory effect on mechanical allodynia in a model of herpetic pain.

Physicochemical Properties

M.Wt	402.43
Formula	C21H14N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[3-(5-thioxo-4H-[1,2,4]oxadiazol-3-yl)phenyl]-1H-naphtho[1, 2-b][1,4]diazepine-2,4(3H,5H)-dione

References

1. Matsumura Y, et al. Sci Rep. 2016 Aug 31;6:32461.

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