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Chemical Structure : NP-1815-PX
Catalog No.: PC-22525Not For Human Use, Lab Use Only.
NP-1815-PX is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.
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NP-1815-PX is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.
NP-1815-PX has no effect on ATP-induced [Ca2+]i increase in hP2X7R- and rP2X3R-1321N1 cells, with IC50 of >30 μM for hP2X1R, rat (r) P2X3R, hP2X2/3R and hP2X7R, and 7.3 μM for hP2X2R.
NP-1815-PX inhibits ATP-mediated responses in primary cultured microglial cells.
NP-1815-PX (10 and 30 pmol/mouse) exhibits an inhibitory effect on mechanical allodynia in a model of herpetic pain.
| M.Wt | 402.43 | |
| Formula | C21H14N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matsumura Y, et al. Sci Rep. 2016 Aug 31;6:32461.
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