Chemical Structure : NP-1815-PX sodium
CAS No.:
1239578-80-3
NP-1815-PX sodium
(P2X4 antagonist)
Catalog No.: PC-22526Not For Human Use, Lab Use Only.
NP-1815-PX sodium is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NP-1815-PX sodium is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.
NP-1815-PX has no effect on ATP-induced [Ca2+]i increase in hP2X7R- and rP2X3R-1321N1 cells, with IC50 of >30 μM for hP2X1R, rat (r) P2X3R, hP2X2/3R and hP2X7R, and 7.3 μM for hP2X2R.
NP-1815-PX inhibits ATP-mediated responses in primary cultured microglial cells.
NP-1815-PX (10 and 30 pmol/mouse) exhibits an inhibitory effect on mechanical allodynia in a model of herpetic pain.
Physicochemical Properties
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M.Wt
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425.42
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Formula
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C21H14N4NaO3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(3-(5-thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-1,5-dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-dione, sodium salt
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References
1. Matsumura Y, et al. Sci Rep. 2016 Aug 31;6:32461.
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