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NP-G2-029

Chemical Structure : NP-G2-029

CAS No.: 1807454-44-9

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NP-G2-029

Catalog No.: PC-24546Not For Human Use, Lab Use Only.

NP-G2-029 is a specific small molecule inhibitor of Fascin (FSCN1) with IC50 of 0.19 uM in F-actin-bundling assay, decreases the migration of mouse and human breast tumor cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NP-G2-029 is a specific small molecule inhibitor of Fascin (FSCN1) with IC50 of 0.19 uM in F-actin-bundling assay, decreases the migration of mouse and human breast tumor cells.
NP-G2-029 decreases the actin-bundling activity of fascin and tumor cell migration.

Physicochemical Properties

M.Wt 400.36
Formula C20H15F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-methyl-N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)isoxazole-5-carboxamide

References

1. Lirui Lin, et al. Front Chem. 2021 Oct 7:9:719949.

2. Gong R, et al. Nat Struct Mol Biol. 2025 Jan 20. doi: 10.1038/s41594-024-01477-2.

3. Huang J, et al. J Mol Biol. 2018 Apr 27;430(9):1324-1335.

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