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NP161

Chemical Structure : NP161

CAS No.: 1421763-05-4

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NP161 (NP 161, NP-161)

Catalog No.: PC-35583Not For Human Use, Lab Use Only.

NP161 is a potent and selective inhibitor of extracellular TRX-1 (Thioredoxin 1) in vitro with IC50 of 0.54 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NP161 is a potent and selective inhibitor of extracellular TRX-1 (Thioredoxin 1) in vitro with IC50 of 0.54 uM.
    NP161 enhances cytokine outputs of alternatively activated macrophages, significantly attenuate TG2 activity and 5-BP incorporation in both M0 and M1 macrophages.

    Physicochemical Properties

    M.Wt 309.402
    Formula C13H15N3O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(cyclohexyldisulfanyl)-5-nitro-1H-benzo[d]imidazole

    References

    1. Plugis NM, et al. Proc Natl Acad Sci U S A. 2018 Aug 13. pii: 201805288.

    2. DiRaimondo TR, et al. J Med Chem. 2013 Feb 14;56(3):1301-10.

    3. Plugis NM, et al. J Biol Chem. 2017 Feb 3;292(5):2000-2008.

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