NP161 |CAS:1421763-05-4 Probechem Biochemicals

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Chemical Structure : NP161

NP161 (NP 161;NP-161)

Catalog No.: PC-35583Not For Human Use, Lab Use Only.

NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM.
NP161 enhances cytokine outputs of alternatively activated macrophages, significantly attenuate TG2 activity and 5-BP incorporation in both M0 and M1 macrophages.

Physicochemical Properties

M.Wt	309.402
Formula	C13H15N3O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(cyclohexyldisulfanyl)-5-nitro-1H-benzo[d]imidazole

References

1. Plugis NM, et al. Proc Natl Acad Sci U S A. 2018 Aug 13. pii: 201805288.

2. DiRaimondo TR, et al. J Med Chem. 2013 Feb 14;56(3):1301-10.

3. Plugis NM, et al. J Biol Chem. 2017 Feb 3;292(5):2000-2008.

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NP161 (NP 161;NP-161)

Biological Activity

Physicochemical Properties

References

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