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NP627

Chemical Structure : NP627

CAS No.: 412962-32-4

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NP627 (NP-627, NP 627)

Catalog No.: PC-73059Not For Human Use, Lab Use Only.

NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.
    NP627 inhibits the cleavage of PKCδI in adipocyte (at 10 nM) and decreases PKCδI kinase activity.
    NP627 does not inhibit other PKC isozyme activities.
    NP627 prevents caspase-3 mediated cleavage of PKCδI, significantly inhibits PKCδI catalytic fragment release, decreases inflammation and apoptosis, and significantly improves mitochondrial metabolism in human adipocytes from obese individuals.

    Physicochemical Properties

    M.Wt 560.571
    Formula C27H28N8O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N'1,N'5-bis(3-(1,3-dioxoisoindolin-2-yl)-1-iminopropyl)glutarohydrazide

    References

    1. Sparks RP, et al. J Biol Chem. 2019 Oct 11;294(41):14896-14910.

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