Chemical Structure : NPAS3 inhibitor 6
CAS No.:
2207-44-5
NPAS3 inhibitor 6
Catalog No.: PC-21007Not For Human Use, Lab Use Only.
NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.
NPAS3 inhibitor 6 effectively down-regulated NPAS3's transcriptional function by disrupting the interface of NPAS3-ARNT complexes at cellular level.
Neuronal PAS domain protein 3 (NPAS3), a basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) family member, is a pivotal transcription factor in neuronal regeneration, development, and related diseases, regulating the expression of downstream genes.
Physicochemical Properties
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M.Wt
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295.35
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Formula
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C10H5N3O2S3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=[N+](C1=CN=C(SC2=NC3=CC=CC=C3S2)S1)[O-]
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References
1. Li P, et al. Bioorg Chem. 2023 Jun 10;139:106676.
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