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NPAS3 inhibitor 6

Chemical Structure : NPAS3 inhibitor 6

CAS No.: 2207-44-5

NPAS3 inhibitor 6

Catalog No.: PC-21007Not For Human Use, Lab Use Only.

NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.
NPAS3 inhibitor 6 effectively down-regulated NPAS3's transcriptional function by disrupting the interface of NPAS3-ARNT complexes at cellular level.
Neuronal PAS domain protein 3 (NPAS3), a basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) family member, is a pivotal transcription factor in neuronal regeneration, development, and related diseases, regulating the expression of downstream genes.

Physicochemical Properties

M.Wt 295.35
Formula C10H5N3O2S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=[N+](C1=CN=C(SC2=NC3=CC=CC=C3S2)S1)[O-]

References

1. Li P, et al. Bioorg Chem. 2023 Jun 10;139:106676.

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