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NPD-001

Chemical Structure : NPD-001

CAS No.: 469863-16-9

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NPD-001 (NPD001)

Catalog No.: PC-47070Not For Human Use, Lab Use Only.

NPD-001 is a potent trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) with IC50 of 4 nM ,and 3 nM, resectively, shows in vitro trypanocidal activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NPD-001 is a potent trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) with IC50 of 4 nM ,and 3 nM, resectively, shows in vitro trypanocidal activities.
    NPD-001 is 10-fold more potent on hPDE4 (hPDE4B1 IC50=0.6 nM) than on TbrPDEB1 (IC50=4 nM).

    Physicochemical Properties

    M.Wt 584.721
    Formula C33H40N6O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4aR,8aS)-4-(3-(4-(4-(1H-tetrazol-5-yl)phenoxy)butoxy)-4-methoxyphenyl)-2-cycloheptyl-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

    References

    1. Veerman J, et al. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.

    2. de Koning HP, et al. J Infect Dis. 2012 Jul 15;206(2):229-37.

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