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Chemical Structure : NPD-001
Catalog No.: PC-47070Not For Human Use, Lab Use Only.
NPD-001 is a potent trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) with IC50 of 4 nM ,and 3 nM, resectively, shows in vitro trypanocidal activities.
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NPD-001 is a potent trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) with IC50 of 4 nM ,and 3 nM, resectively, shows in vitro trypanocidal activities.
NPD-001 is 10-fold more potent on hPDE4 (hPDE4B1 IC50=0.6 nM) than on TbrPDEB1 (IC50=4 nM).
| M.Wt | 584.721 | |
| Formula | C33H40N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Veerman J, et al. Bioorg Med Chem. 2016 Apr 1;24(7):1573-81.
2. de Koning HP, et al. J Infect Dis. 2012 Jul 15;206(2):229-37.
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