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Chemical Structure : NPD-008
Catalog No.: PC-47069Not For Human Use, Lab Use Only.
NPD-008 is a potent, selective Trypanosoma brucei PDE B1 (TbrPDEB1) inhibitor with Ki of 100 nM, exhibits antitrypanosomal effects with IC50 of 5.5 uM.
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NPD-008 is a potent, selective Trypanosoma brucei PDE B1 (TbrPDEB1) inhibitor with Ki of 100 nM, exhibits antitrypanosomal effects with IC50 of 5.5 uM.
NPD-008 displays 10-fold selectivity over hPDE4B1.
Incubation of bloodstream form trypanosomes with NPD-008 increased intracellular cAMP levels in T. b. brucei in a dose-dependent fashion.
| M.Wt | 528.65 | |
| Formula | C31H36N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Blaazer AR, et al. J Med Chem. 2018 May 10;61(9):3870-3888.
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