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NPD-008

Chemical Structure : NPD-008

CAS No.: 2229043-42-7

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NPD-008 (NPD008)

Catalog No.: PC-47069Not For Human Use, Lab Use Only.

NPD-008 is a potent, selective Trypanosoma brucei PDE B1 (TbrPDEB1) inhibitor with Ki of 100 nM, exhibits antitrypanosomal effects with IC50 of 5.5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NPD-008 is a potent, selective Trypanosoma brucei PDE B1 (TbrPDEB1) inhibitor with Ki of 100 nM, exhibits antitrypanosomal effects with IC50 of 5.5 uM.
    NPD-008 displays 10-fold selectivity over hPDE4B1.
    Incubation of bloodstream form trypanosomes with NPD-008 increased intracellular cAMP levels in T. b. brucei in a dose-dependent fashion.

    Physicochemical Properties

    M.Wt 528.65
    Formula C31H36N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-amino-2-oxoethyl)-5'-((4aS,8aR)-3-cycloheptyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carboxamide

    References

    1. Blaazer AR, et al. J Med Chem. 2018 May 10;61(9):3870-3888.

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