NPD389 | ME2 inhibitor | Probechem Biochemicals

Chemical Structure : NPD389

NPD389 (NPD 389)

Catalog No.: PC-49093Not For Human Use, Lab Use Only.

NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrate NAD+.

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Biological Activity

NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrate NAD+.

Physicochemical Properties

M.Wt	352.342
Formula	C20H16O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3',6'-dihydroxy-4,4''-dimethoxy-[1,1':4',1''-terphenyl]-2',5'-dione

References

1. Yi Wen, et al. Acta Pharmacol Sin. 2014 May;35(5):674-84.

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NPD389 (NPD 389)

Biological Activity

Physicochemical Properties

References

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