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Chemical Structure : NPD8790
Catalog No.: PC-22334Not For Human Use, Lab Use Only.
NPD8790 is a species-selective inhibitor of mitochondrial respiratory complex I with IC50 of 1.6, 2.1 and 1.1 uM for C. briggsae, P. pacificus and P. hermaphrodita complex I, respectively, does not inhibit human mitochondria with IC50 of >75 uM.
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NPD8790 is a species-selective inhibitor of mitochondrial respiratory complex I with IC50 of 1.6, 2.1 and 1.1 uM for C. briggsae, P. pacificus and P. hermaphrodita complex I, respectively, does not inhibit human mitochondria with IC50 of >75 uM.
NPD8790 shows lethal activity in the C. elegans RQ-dependent metabolism assay in vivo.
NPD8790 affects H. polygyrus, a mouse soil-transmitted helminth.
| M.Wt | 292.43 | |
| Formula | C20H24N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Taylor Davie, et al. Nat Commun. 2024 May 8;15(1):3367.
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