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NPD926

Chemical Structure : NPD926

CAS No.: 384361-79-9

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NPD926 (NPD-926, NPD 926)

Catalog No.: PC-61519Not For Human Use, Lab Use Only.

NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.

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    Biological Activity

    NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.
    NPD926 preferentially induces effects in KRAS-transformed fibroblast cells, compared with their untransformed counterparts, sensitizes cells to inhibitors of system x(c)⁻, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells.

    Physicochemical Properties

    M.Wt 479.061
    Formula C29H35ClN2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-chloro-N-(4-(dimethylamino)benzyl)-N-(3-(4-isopropoxyphenyl)-3-phenylpropyl)acetamide

    References

    1. Kawamura T, et al. Biochem J. 2014 Oct 1;463(1):53-63.

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