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Chemical Structure : NPD926
Catalog No.: PC-61519Not For Human Use, Lab Use Only.
NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.
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NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.
NPD926 preferentially induces effects in KRAS-transformed fibroblast cells, compared with their untransformed counterparts, sensitizes cells to inhibitors of system x(c)⁻, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells.
| M.Wt | 479.061 | |
| Formula | C29H35ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawamura T, et al. Biochem J. 2014 Oct 1;463(1):53-63.
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