NPS-2143 |CAS:284035-33-2 Probechem Biochemicals

Chemical Structure : NPS-2143

CAS No.: 284035-33-2

NPS-2143 (NPS 2143;SB-262470;NPS2143;SB 262470)

Catalog No.: PC-42051Not For Human Use, Lab Use Only.

NPS-2143 (SB262470) is a potent, selective and orally active CaSR antagonist with IC50 of 43 nM.

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25 mg	$148	In stock
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Biological Activity

NPS-2143 (SB262470) is a potent, selective and orally active CaSR antagonist with IC50 of 43 nM.
NPS-2143 (SB262470) does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors.
NPS-2143 (SB262470) stimulates parathyroid hormone (PTH ) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo.
NPS-2143 (SB262470) also inhibits lipopolysaccharide-induced pulmonary inflammation.

Physicochemical Properties

M.Wt	408.9205
Formula	C24H25ClN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-

References

1. Gowen M, et al. J Clin Invest. 2000 Jun;105(11):1595-604.

2. Nemeth EF, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

3. Lee JW, et al. Mol Immunol. 2017 Oct;90:150-157.

NPS-2143 (NPS 2143;SB-262470;NPS2143;SB 262470)

Biological Activity

Physicochemical Properties

References

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