NR162 is a specific small molecule inhibitor of CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) with IC50 of 0.08 uM, and ITC binding Kd of 22 nM.
NR162 has no effect of 26 on cellular growth or toxicity at 10 uM against NCI60 panel of cancer cell lines.
NR162 shows littile to no activity against TYRO3, MERTK, AXL, ABL1 and CSNK1E
NR162 is a potent and highly selective tool compound studying the diverse functions of CASK as well as exploring its potential as a possible target for pharmaceutical intervention.
