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NR2F1 agonist C26

Chemical Structure : NR2F1 agonist C26

CAS No.: 374101-64-1

NR2F1 agonist C26

Catalog No.: PC-38249Not For Human Use, Lab Use Only.

NR2F1 agonist C26 is a specific agonist of nuclear receptor NR2F1, significantly induces luciferase expression by 1.7- and 1.9-fold at 0.5 and 1 uM in RARE-luciferase bioassays.

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    Biological Activity

    NR2F1 agonist C26 is a specific agonist of nuclear receptor NR2F1, significantly induces luciferase expression by 1.7- and 1.9-fold at 0.5 and 1 uM in RARE-luciferase bioassays.
    NR2F1 agonist C26 does not bind and activate RXRα.
    NR2F1 agonist C26 up-regulates NR2F1 and downstream target genes that regulate dormancy, mRNA levels of SOX9, RARβ, and p27 are all significantly upregulated in C26-treated tumors compared with control.
    NR2F1 agonist C26 induces transcriptional changes associated with inhibition of cell cycle progression and mTOR signaling, metastasis suppression, and induction of a neural crest lineage program, and inhibits lung HNSCC metastasis in mice.

    Physicochemical Properties

    M.Wt 470.635
    Formula C28H30N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one

    References

    1. Bassem D Khalil, et al. J Exp Med. 2022 Jan 3;219(1):e20210836.

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