Chemical Structure : NR5A2 inhibitor Cmp3d2
CAS No.:
1185486-16-1
NR5A2 inhibitor Cmp3d2
Catalog No.: PC-21459Not For Human Use, Lab Use Only.
NR5A2 inhibitor Cmp3d2 is a specific small molecule inhibitor of NR5A2 (liver receptor homolog-1, LRH-1) with Kd of 1.8 uM in Biacore-based assays, inhibits the transcriptional activity of hLRH-1 with IC50 of 6 uM (G0S2 mRNA level).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NR5A2 inhibitor Cmp3d2 is a specific small molecule inhibitor of NR5A2 (liver receptor homolog-1, LRH-1) with Kd of 1.8 uM in Biacore-based assays, inhibits the transcriptional activity of hLRH-1 with IC50 of 6 uM (G0S2 mRNA level).
NR5A2 inhibitor Cmp3d2 reduces tumor necrosis factor (TNF) production and associated decreased liver damage in a macrophage- and TNF-dependent mouse model of hepatitis.
Physicochemical Properties
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M.Wt
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364.50
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Formula
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C21H28N6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(3-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-3-yl}phenyl)-N,N-5,6-tetramethyl-2-pyrimidinamine
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References
1. Cindy Benod, et al. J Biol Chem. 2013 Jul 5;288(27):19830-44.
2. Juliane Schwaderer, et al. Cell Death Dis. 2020 Feb 28;11(2):154.
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