NRAS-G4 inhibitor 18

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Chemical Structure : NRAS-G4 inhibitor 18

Catalog No.: PC-20884Not For Human Use, Lab Use Only.

NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.
NRAS-G4 inhibitor 18 exhibits weak binding toward the RNA-G4 structure formed by AKTIP and DNA-G4 from BCL2, and no significant quenching for other G4s.
NRAS-G4 inhibitor 18 inhibits the translation of NRAS in vitro but showed only moderate effects on the NRAS levels in cellulo.

Physicochemical Properties

M.Wt	486.55
Formula	C25H22N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=S(C1=CC=C(CCNC2=C3C=CC=CC3=NC(C4=NN=C(C5=CC=C(C)C=C5)O4)=N2)C=C1)(N)=O

References

1. Balaratnam S, et al. Cell Chem Biol. 2023 May 26:S2451-9456(23)00140-X.

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