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Chemical Structure : NRAS-G4 inhibitor 18
Catalog No.: PC-20884Not For Human Use, Lab Use Only.
NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.
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NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.
NRAS-G4 inhibitor 18 exhibits weak binding toward the RNA-G4 structure formed by AKTIP and DNA-G4 from BCL2, and no significant quenching for other G4s.
NRAS-G4 inhibitor 18 inhibits the translation of NRAS in vitro but showed only moderate effects on the NRAS levels in cellulo.
| M.Wt | 486.55 | |
| Formula | C25H22N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Balaratnam S, et al. Cell Chem Biol. 2023 May 26:S2451-9456(23)00140-X.
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