You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-JAK-NS-018 maleate
NS-018 maleate

Chemical Structure : NS-018 maleate

CAS No.: 1354799-87-3

NS-018 maleate (NS018 maleate, Ilginatinib maleate)

Catalog No.: PC-45662Not For Human Use, Lab Use Only.

NS-018 maleate (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).

Packing Price Stock Quantity
5 mg $218 In stock
10 mg $348 In stock
25 mg $558 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NS-018 maleate (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).
NS-018 displays 30-50-fold greater selectivity for JAK2 over JAK1, JAK3 and Tyk2.
NS-018 also inhibits Src family kinases(Src, Fyn).
NS-018 shows effective in mouse Ba/F3-JAK2V617F disease model.

Physicochemical Properties

M.Wt 505.501
Formula C25H24FN7O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

2,6-Pyridinediamine, N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-, (2Z)-2-butenedioate (1:1)

References

1. Nakaya Y, et al. Blood Cancer J. 2011 Jul;1(7):e29.

2. Nakaya Y, et al. Blood Cancer J. 2014 Jan 10;4:e174.

3. Kuroda J, et al. Leuk Res. 2014 May;38(5):619-24.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: