Chemical Structure : NS-229 4-methylbenzenesulfonate monohydrate
CAS No.:
2130838-42-3
NS-229 4-methylbenzenesulfonate monohydrate
Catalog No.: PC-26018Not For Human Use, Lab Use Only.
NS-229 4-methylbenzenesulfonate monohydrate is a potent, selective JAK1 inhibitor with IC50 of 52 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NS-229 4-methylbenzenesulfonate monohydrate is a potent, selective JAK1 inhibitor with IC50 of 52 nM.
NS-229 significantly decreased the expression of CD69 induced by IL-5 in human peripheral blood eosinophils.
NS-229 significantly decreased the production of cytokines such as interferon gamma, IL-5, and IL-13, induced by anti-CD3/CD28 antibody, in human peripheral blood mononuclear cells.
NS-229 shows suppression of multiple cytokine signals and inhibition of vascular lesion formation without impacting the relevant side-effect parameters.
Physicochemical Properties
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M.Wt
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659.78
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Formula
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C29H37N7O7S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Methyl (1-{[6-{[(1S)-1-cyclopropylethyl]amino}-2-(pyrazolo[5,1-b][1,3]thiazol-7-yl)pyrimidin-4-yl]carbonyl}piperidin-4-yl)carbamate mono(4-methylbenzenesulfonate) monohydrate
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References
1. Patent WO2016035814 A1 (Compound II).
2. Kageyama K, et al. J Pharmacol Exp Ther. 2026 Jan 7;393(2):103806.
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