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NS11394

Chemical Structure : NS11394

CAS No.: 951650-22-9

NS11394 (NS-11394)

Catalog No.: PC-42797Not For Human Use, Lab Use Only.

NS11394 is a potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NS11394 is a potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2.
NS11394 displays 600 to 2000-fold over GABAA-α4 or GABAA-α6 containing receptors.
NS11394 exhibits in vivo anxiolytic efficacy, attenuates spontaneous nociceptive behaviors in response to hindpaw injection of formalin and capsaicin in rats.

Physicochemical Properties

M.Wt 353.4165
Formula C23H19N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 43 mg/mL

Chemical Name/SMILES

[1,1'-Biphenyl]-2-carbonitrile, 3'-[5-(1-hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-

References

1. Mirza NR, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68.

2. Munro G, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):969-81.

3. Munro G, et al. Neuropharmacology. 2011 Jul-Aug;61(1-2):121-32.

4. Spröte C, et al. Eur J Pharmacol. 2016 Nov 15;791:655-658.

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