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Chemical Structure : NS11394
CAS No.: 951650-22-9
Catalog No.: PC-42797Not For Human Use, Lab Use Only.
A potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $176 | In stock | |
| 50 mg | $688 | In stock | |
| 100 mg | Get quote |
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A potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2; displays 600 to 2000-fold over GABAA-α4 or GABAA-α6 containing receptors; exhibits in vivo anxiolytic efficacy, attenuates spontaneous nociceptive behaviors in response to hindpaw injection of formalin and capsaicin in rats.
| M.Wt | 353.4165 | |
| Formula | C23H19N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 43 mg/mL |
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| Chemical Name/SMILES |
[1,1'-Biphenyl]-2-carbonitrile, 3'-[5-(1-hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]- |
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1. Mirza NR, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68.
2. Munro G, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):969-81.
3. Munro G, et al. Neuropharmacology. 2011 Jul-Aug;61(1-2):121-32.
4. Spröte C, et al. Eur J Pharmacol. 2016 Nov 15;791:655-658.
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