Catalog No.: PC-49742Not For Human Use, Lab Use Only.
NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM.
NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM.
NS3694 inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
NS3694 inhibits the association of caspase 9 to Apaf-1.
NS3694 blocks the formation of the 700-kDa apoptosome complex. NS3694 (10-100 uM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.
NS3694 inhibits TNF- and staurosporine-induced effector caspase activation and TNF-induced apoptosis in ME-180as cells.
NS3694 does not inhibit FasL-induced DEVDase activity or FasL-induced cytotoxicity in SKW6.4 cells.
