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Chemical Structure : NS3694
CAS No.: 426834-38-0
Catalog No.: PC-49742Not For Human Use, Lab Use Only.
NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM.
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|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
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NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM.
NS3694 inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
NS3694 inhibits the association of caspase 9 to Apaf-1.
NS3694 blocks the formation of the 700-kDa apoptosome complex. NS3694 (10-100 uM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.
NS3694 inhibits TNF- and staurosporine-induced effector caspase activation and TNF-induced apoptosis in ME-180as cells.
NS3694 does not inhibit FasL-induced DEVDase activity or FasL-induced cytotoxicity in SKW6.4 cells.
| M.Wt | 358.70 | |
| Formula | C15H10ClF3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzoic acid |
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1. Ulrik Lademann, et al. Mol Cell Biol. 2003 Nov;23(21):7829-37.
2. Zhao CQ, et al. Age (Dordr). 2010 Jun;32(2):161-77.
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