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NSC13728

Chemical Structure : NSC13728

CAS No.: 718587-49-6

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NSC13728 (NSC-13728)

Catalog No.: PC-20798Not For Human Use, Lab Use Only.

NSC13728 is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC13728 is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
    NSC13728 does not significantly enhance DNA binding of the Myc-Max heterodimer or of the Max homodimer, as determined by EMSA analysis.
    NSC13728 reduces the association of Myc with Max in a dose-dependent manner in MCF7-35IM cells.
    NSC13728 inhibited the Myc-induced formation of transformed cell foci in CEF and growth inhibition in Q8 cells with IC50 of 3 uM.
    NSC13728 inhibits growth and complements growth reduction by ICI 182,780 in MCF7-35IM cells.

    Physicochemical Properties

    M.Wt 464.66
    Formula C31H36N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    bis(4-methyl-2-(piperidin-1-yl)quinolin-6-yl)methane

    References

    1. Hao Jiang, et al. Mol Pharmacol. 2009 Sep;76(3):491-502.

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