NSC13728 hydrochloride is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
NSC13728 does not significantly enhance DNA binding of the Myc-Max heterodimer or of the Max homodimer, as determined by EMSA analysis.
NSC13728 reduces the association of Myc with Max in a dose-dependent manner in MCF7-35IM cells.
NSC13728 inhibited the Myc-induced formation of transformed cell foci in CEF and growth inhibition in Q8 cells with IC50 of 3 uM.
NSC13728 inhibits growth and complements growth reduction by ICI 182,780 in MCF7-35IM cells.
