Chemical Structure : NSC13728 hydrochloride
CAS No.: 5463-36-5
Catalog No.: PC-20799Not For Human Use, Lab Use Only.
NSC13728 hydrochloride is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
Packing | Price | Stock | Quantity |
---|---|---|---|
10 mg | $188 | In stock | |
25 mg | $298 | In stock | |
50 mg | $488 | In stock | |
100 mg | Get quote | ||
1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NSC13728 hydrochloride is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization.
NSC13728 does not significantly enhance DNA binding of the Myc-Max heterodimer or of the Max homodimer, as determined by EMSA analysis.
NSC13728 reduces the association of Myc with Max in a dose-dependent manner in MCF7-35IM cells.
NSC13728 inhibited the Myc-induced formation of transformed cell foci in CEF and growth inhibition in Q8 cells with IC50 of 3 uM.
NSC13728 inhibits growth and complements growth reduction by ICI 182,780 in MCF7-35IM cells.
M.Wt | 501.12 | |
Formula | C31H37ClN4 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
CC1=CC(N2CCCCC2)=NC3=CC=C(CC4=CC=C5N=C(N6CCCCC6)C=C(C)C5=C4)C=C13.[H]Cl |
1. Hao Jiang, et al. Mol Pharmacol. 2009 Sep;76(3):491-502.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright