Catalog No.: PC-61797Not For Human Use, Lab Use Only.
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM.
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM.
SC 145366 increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding.
SC 145366 causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
