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Chemical Structure : NSC 145366
Catalog No.: PC-61797Not For Human Use, Lab Use Only.
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM.
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NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
| M.Wt | 635.371 | |
| Formula | C37H63ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thomas FM, et al. SLAS Discov. 2017 Jul;22(6):706-719.
2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug;1861(8):1992-2006.
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