Catalog No.: PC-27805Not For Human Use, Lab Use Only.
NSC146109 (XI-011) hydrochloride is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression.
NSC146109 (XI-011) hydrochloride is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. NSC146109 (XI-011) activates p53 by increasing its stability, significantly extends the half-life of p53. NSC146109 (XI-011) (0.5 uM) induces apoptosis in breast cancer cell MCF-7. NSC146109 (XI-011) inhibits MDMX gene transcription, decreases the viability of breast cancer cells expressing a low level of MDMX in a less-efficient manner. NSC146109 (XI-011) decreases the viability of breast cancer cells in collaboration with Nutlin-3a.
