NSC23005 sodium (p18-IN-40) is a specific, effective p18 (p18INK4C) inhibitor that can selectively promote HSCs expansion with EC50 of 5.21 nM.
NSC23005 sodium inhibits p18, and then activates CDK4/6, promotes HSCs expansion in both murine and human models.
NSC23005 sodium shows no activity in promoting the proliferation of leukemia cells, and no significant cytotoxicity toward 32D cells or HSCs.
Physicochemical Properties
M.Wt
305.33
Formula
C13H16NNaO4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 6.4 mg/mL (Need ultrasonic)
Chemical Name/SMILES
Benzoic acid, 4-[(cyclohexylamino)sulfonyl]-, sodium salt (1:1)
