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NSC232003

Chemical Structure : NSC232003

CAS No.: 1905453-18-0

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NSC232003 (NSC 232003)

Catalog No.: PC-49682Not For Human Use, Lab Use Only.

NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation.

Physicochemical Properties

M.Wt 169.14
Formula C6H7N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-5-(1-(hydroxyamino)ethylidene)pyrimidine-2,4(3H,5H)-dione

References

1. Vassilios Myrianthopoulos, et al. Eur J Med Chem. 2016 May 23;114:390-6.

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