NSC290956 (Spiclomazine, Clospirazine) is a small molecule inhibitor of KRas with Kd of 21.3 uM.
NSC290956 inhibits KRas activity and downstream signaling events in KRas-driven nuytant NSCLC cells, decreases the cellular viability, cell cycle, and migration.
NSC290956 changes KRas-dependent metabolic phenotype in Non-small-cell lung cancer cells, regulates mitochondrial dysfunction for apoptosis in both A549 and H358 cells.
NSC290956 shows activity in the KRas mutant cell line xenograft.
