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Chemical Structure : NSC 45576
Catalog No.: PC-63107Not For Human Use, Lab Use Only.
NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.
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NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.
NSC 45576 inhibits cAMP-induced EPAC activation while not affecting PKA activity.
NSC 45576 is a valuable pharmacological tools for elucidating the biological functions of EPAC and for promoting an understanding of disease mechanisms related to EPAC/cAMP signaling.
| M.Wt | 378.402 | |
| Formula | C20H14N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tsalkova T, et al. PLoS One. 2012;7(1):e30441.
2. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.
3. Mizuta K, et al. Respir Res. 2013 Sep 2;14:89.
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