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NSC 45576

Chemical Structure : NSC 45576

CAS No.: 1414586-62-1

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NSC 45576 (NSC45576)

Catalog No.: PC-63107Not For Human Use, Lab Use Only.

NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.
NSC 45576 inhibits cAMP-induced EPAC activation while not affecting PKA activity.
NSC 45576 is a valuable pharmacological tools for elucidating the biological functions of EPAC and for promoting an understanding of disease mechanisms related to EPAC/cAMP signaling.

Physicochemical Properties

M.Wt 378.402
Formula C20H14N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(2-(2-oxonaphthalen-1(2H)-ylidene)hydrazinyl)naphthalene-2-sulfonic acid

References

1. Tsalkova T, et al. PLoS One. 2012;7(1):e30441.

2. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.

3. Mizuta K, et al. Respir Res. 2013 Sep 2;14:89.

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