NSC 621601 (Compound Q34) is a potent, specific inhibitor of SARS-CoV-2 cellular entry with IC50 of 15 uM.
Compound Q34 inhibits cellular entry of virus mediated by the SARS-CoV-2 spike protein specifically, but not by the VSV-G glycoprotein.
Compound Q34 inhibits SARS-CoV-2 cellular entry with a broad safety dose range.
Compound Q34 inhibits infection of SARS-CoV-2 pseudovirus in a dose-dependent manner and exhibits no cytotoxicity in a broad dose range.
Compound Q34 inhibits authentic SARS-CoV-2 infection of hACE2-HEK cells.
Compound Q34 inhibits authentic SAR-CoV-2 infection of human iPSC-derived neurons and astrocytes, and human lung cells.
Physicochemical Properties
M.Wt
354.454
Formula
C20H26N4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N,N'-bis(phenylalanyl)ethane-1,2-diamine
References
1. Qi Cui, et al. iScience. 2022 Jan 21;25(1):103684.
