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NSC 625987

Chemical Structure : NSC 625987

CAS No.: 141992-47-4

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NSC 625987 (NSC625987)

Catalog No.: PC-62680Not For Human Use, Lab Use Only.

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Physicochemical Properties

M.Wt 271.33
Formula C15H13NO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Dimethoxy-9(10H)-acridinethione

References

1. Kubo A, et al. Clin Cancer Res. 1999 Dec;5(12):4279-86.

2. McInnes C, et al. Chem Biol. 2004 Apr;11(4):525-34.

3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.

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