NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A.
NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells, inhibits NF-κB activation induced by PMA, but not by TNFα.
NSC697923 specifically inhibits Ubc13-mediated polyubiquitin chain synthesis in vitro, does not inhibits UbcH5c-mediated polyubiquitin chain formation.
NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells.
Physicochemical Properties
M.Wt
267.255
Formula
C11H9NO5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-nitro-5-tosylfuran
References
1. Pulvino M, et al. Blood. 2012 Aug 23;120(8):1668-77.
2. Cheng J, et al. Cell Death Dis. 2014 Feb 20;5:e1079.
3. Ritorto MS, et al. Nat Commun. 2014 Aug 27;5:4763.
