NSC74429 | PHLPP inhibitor | Probechem Biochemicals

Chemical Structure : NSC74429

NSC74429 (NSC 74429)

Catalog No.: PC-21043Not For Human Use, Lab Use Only.

NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.

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Biological Activity

NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.
NSC74429 increased 24 h neuronal survival in both the glutamate (at 50 µM) and H2O2 injury assay (at 25 and 50 µM).
NSC74429 (1 mg/kg) exhibits hippocampal neuroprotection mouse model of severe traumatic brain injury (TBI), significantly increased CA1 neuronal survival.

Physicochemical Properties

M.Wt	308.36
Formula	C15H12N6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-di(1H-indazol-6-yl)thiourea

References

1. Travis C Jackson, et al. Biomolecules. 2022 Sep 23;12(10):1352.

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NSC74429 (NSC 74429)

Biological Activity

Physicochemical Properties

References

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