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Chemical Structure : NSC74429
Catalog No.: PC-21043Not For Human Use, Lab Use Only.
NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.
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NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay.
NSC74429 increased 24 h neuronal survival in both the glutamate (at 50 µM) and H2O2 injury assay (at 25 and 50 µM).
NSC74429 (1 mg/kg) exhibits hippocampal neuroprotection mouse model of severe traumatic brain injury (TBI), significantly increased CA1 neuronal survival.
| M.Wt | 308.36 | |
| Formula | C15H12N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Travis C Jackson, et al. Biomolecules. 2022 Sep 23;12(10):1352.
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