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NSC 745887

Chemical Structure : NSC 745887

CAS No.: 54490-26-5

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NSC 745887 (NSC745887)

Catalog No.: PC-63230Not For Human Use, Lab Use Only.

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.
    NSC 745887 increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage.
    NSC 745887 suppresses the [18F]-FDG-specific uptake value in brain tumors.

    Physicochemical Properties

    M.Wt 260.252
    Formula C16H8N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Naphtho[2,3-f]quinoxaline-7,12-dione

    References

    1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.

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