NSC95397 is a potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively.
NSC95397 displays 125- and 180-fold selectivity over VH1-related dual-specificity phosphatase and PTP1B.
NSC95397 shows significant growth inhibition in cancer cells and blocks G(2)/M phase transition.
NSC95397 also inhibits cellular MKP-1 and MKP-3 with IC50 of 13 uM.
Physicochemical Properties
M.Wt
310.38
Formula
C14H14O4S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
References
1. Lazo JS, et al. Mol Pharmacol. 2002 Apr;61(4):720-8.
2. Nemoto K, et al. Prostate. 2004 Jan 1;58(1):95-102.
3. Vogt A, et al. Mol Cancer Ther. 2008 Feb;7(2):330-40.
4. Larsson DE, et al. Anticancer Res. 2010 Jan;30(1):149-56.
