NTRC 0066-0 is a highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM.
NTRC 0066-0 displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4.
NTRC 0066-0 shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM).
NTRC 0066-0 increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel.
