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Chemical Structure : NTRC 0066-0
CAS No.: 1817791-73-3
Catalog No.: PC-61464Not For Human Use, Lab Use Only.
NTRC 0066-0 is a highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NTRC 0066-0 is a highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM.
NTRC 0066-0 displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4.
NTRC 0066-0 shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM).
NTRC 0066-0 increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel.
| M.Wt | 565.722 | |
| Formula | C33H39N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-4,5-dihydro-7,9,9b-triaza-cyclopenta[a]naphthalene-3-carboxylic acid (2,6-diethyl-phenyl)-amide |
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1. Maia AR, et al. Ann Oncol. 2015 Oct;26(10):2180-92.
2. Libouban MAA, et al. Oncotarget. 2017 Jun 13;8(24):38309-38325.
3. Zaman GJR, et al. Mol Cancer Ther. 2017 Jul 27. pii: molcanther.0342.2017.
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