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NU-7163

Chemical Structure : NU-7163

CAS No.: 503468-03-9

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NU-7163 (NU7163;NU 7163)

Catalog No.: PC-70103Not For Human Use, Lab Use Only.

NU-7163 is a poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NU-7163 is a poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM.
    NU-7163 exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α。
    NU-7163 sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro.

    Physicochemical Properties

    M.Wt 295.338
    Formula C18H17NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-methylmorpholino)-4H-benzo[h]chromen-4-one

    References

    1. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85.

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