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NU7441

Chemical Structure : NU7441

CAS No.: 503468-95-9

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NU7441 (KU 57788, NU-7441, KU57788)

Catalog No.: PC-42782Not For Human Use, Lab Use Only.

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor (IC50=14 nM).

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10 mg $68 In stock
25 mg $118 In stock
50 mg $198 In stock
100 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor (IC50=14 nM).
NU7441 (KU 57788) also modestly inhibits BRD4 and BRDT with IC50 of 1 uM and 3.5 uM respectively.
NU7441 (KU 57788) also stimulates Cas9-mediated genome editing.

Physicochemical Properties

M.Wt 413.4883
Formula C25H19NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-

References

1. Leahy JJ, et al. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.

2. Robert F, et al. Genome Med. 2015 Aug 27;7:93.

3. Ember SW, et al. ACS Chem Biol. 2014 May 16;9(5):1160-71.

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