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Chemical Structure : NUCC-390 dihydrochloride
CAS No.: 2749281-71-6
Catalog No.: PC-20291Not For Human Use, Lab Use Only.
NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
NUCC-390 induces internalization of CXCR4 receptors.
NUCC-390 displays increased levels of phosphorylated ERK (pERK) in treated C8161 cells.
The effects of NUCC-390 could be completely inhibited by the selective CXCR4 antagonist AMD3100 (Cat#PC-42164).
NUCC-390 stimulates axonal growth and elongation via CXCR4 in cultured cerebellar granule neurons (CGNs), and in primary cultures of rat spinal cord motor neurons (SCMNs).
NUCC-390 promotes functional and anatomical recovery of the neuromuscular junction (NMJ) in mice.
NUCC-390 acts very similarly to the natural agonist ligand, the chemokine CXCL12α.
| M.Wt | 468.47 | |
| Formula | C23H35Cl2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, 1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-, hydrochloride (1:2) |
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1. Negro S, et al. Cells. 2019 Sep 30;8(10):1183.
2. Mishra R, et al. Sci Rep. 2016 Jul 26:6:30155.
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