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Chemical Structure : NUCC-390 dihydrochloride
Catalog No.: PC-20291Not For Human Use, Lab Use Only.
NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
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NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
NUCC-390 induces internalization of CXCR4 receptors.
NUCC-390 displays increased levels of phosphorylated ERK (pERK) in treated C8161 cells.
The effects of NUCC-390 could be completely inhibited by the selective CXCR4 antagonist AMD3100 (Cat#PC-42164).
NUCC-390 stimulates axonal growth and elongation via CXCR4 in cultured cerebellar granule neurons (CGNs), and in primary cultures of rat spinal cord motor neurons (SCMNs).
NUCC-390 promotes functional and anatomical recovery of the neuromuscular junction (NMJ) in mice.
NUCC-390 acts very similarly to the natural agonist ligand, the chemokine CXCL12α.
| M.Wt | 468.47 | |
| Formula | C23H35Cl2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Negro S, et al. Cells. 2019 Sep 30;8(10):1183.
2. Mishra R, et al. Sci Rep 6:30155.
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