NUCC-390 dihydrochloride (NUCC390) is a small molecule agonist of CXCR4, recapitulates the activity of CXCL12α.
NUCC-390 induces internalization of CXCR4 receptors.
NUCC-390 displays increased levels of phosphorylated ERK (pERK) in treated C8161 cells.
The effects of NUCC-390 could be completely inhibited by the selective CXCR4 antagonist AMD3100 (Cat#PC-42164).
NUCC-390 stimulates axonal growth and elongation via CXCR4 in cultured cerebellar granule neurons (CGNs), and in primary cultures of rat spinal cord motor neurons (SCMNs).
NUCC-390 promotes functional and anatomical recovery of the neuromuscular junction (NMJ) in mice.
NUCC-390 acts very similarly to the natural agonist ligand, the chemokine CXCL12α.
