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NV848

Chemical Structure : NV848

CAS No.: 58535-41-4

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NV848 (NV 848)

Catalog No.: PC-20936Not For Human Use, Lab Use Only.

NV848 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NV848 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.
NV848 can improve myeloid differentiation in bone marrow hematopoietic progenitors, enhancing neutrophil maturation and reducing the number of dysplastic granulocytes in vitro.
NV848 can restore full-length SBDS protein synthesis as well, showing very low toxicity in zebrafish.

Physicochemical Properties

M.Wt 141.13
Formula C5H7N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CC(NC1=NOC(C)=N1)=O

References

1. Bezzerri V, et al. iomedicines. 2022 Apr 12;10(4):886.

2. Carollo PS, et al Int J Mol Sci. 2023 Jun 1;24(11):9609. .

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