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Chemical Structure : NV848
Catalog No.: PC-20936Not For Human Use, Lab Use Only.
NV848 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.
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NV848 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo.
NV848 can improve myeloid differentiation in bone marrow hematopoietic progenitors, enhancing neutrophil maturation and reducing the number of dysplastic granulocytes in vitro.
NV848 can restore full-length SBDS protein synthesis as well, showing very low toxicity in zebrafish.
| M.Wt | 141.13 | |
| Formula |
C5H7N3O2 |
|
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Bezzerri V, et al. iomedicines. 2022 Apr 12;10(4):886.
2. Carollo PS, et al Int J Mol Sci. 2023 Jun 1;24(11):9609. .
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