NVP-ACC789 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 20 nM, weakly inhibits VEGFR-1, 3 with IC50 of 180 and 380 nM.
NVP-ACC789 shows no activity against FGFR-1, FGFR-3, FGFR-4, PDGFR-α, and Tie-2 tyrosine kinases at 10 uM.
NVP-ACC789 inhibits VEGF-induced cellular receptor phosphorylation with IC50 of 11.5 nM in cell-based assays, inhibits VEGF-induced HUVE cell proliferation with IC50 of 1.6 nM.
