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NVP-BEP800

Chemical Structure : NVP-BEP800

CAS No.: 847559-80-2

NVP-BEP800 (VER-82576, VER82576)

Catalog No.: PC-42748Not For Human Use, Lab Use Only.

NVP-BEP800 (VER-82576) is a potent and selective Hsp90β inhibitor with IC50 of 58 nM.

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5 mg $88 In stock
10 mg $128 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NVP-BEP800 (VER-82576) is a potent and selective Hsp90β inhibitor with IC50 of 58 nM.
NVP-BEP800 shows >70-fold selective against Grp94 and Trap-1.
NVP-BEP800 induces ErbB2, B-Raf(V600E), Raf-1, Akt and Hsp70 induction in A375 melanoma and BT-474 breast cancer cell lines.
NVP-BEP800 is orally bioactive.

Physicochemical Properties

M.Wt 480.4106
Formula C21H23Cl2N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.2 mg/mL (Need ultrasonic)

Chemical Name/SMILES

Thieno[2,3-d]pyrimidine-6-carboxamide, 2-amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl-

References

1. Massey AJ, et al. Mol Cancer Ther. 2010 Apr;9(4):906-19.

2. Brough PA, et al. J Med Chem. 2009 Aug 13;52(15):4794-809.

3. Stingl L, et al. Br J Cancer. 2010 May 25;102(11):1578-91.

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