Chemical Structure : NVP-BHG712
CAS No.: 940310-85-0
Catalog No.: PC-43438Not For Human Use, Lab Use Only.
NVP-BHG712 is a potent, specific inhibitor of EphB4 kinase that inhibits EphB4 autophosphorylation with IC50 of 25 nM in cell-bases assays, displays little to no activity against VEGFR2, IGF1R and InsR.
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NVP-BHG712 is a potent, specific inhibitor of EphB4 kinase that inhibits EphB4 autophosphorylation with IC50 of 25 nM in cell-bases assays, displays little to no activity against VEGFR2, IGF1R and InsR.
NVP-BHG712 dose dependently inhibits autophosphorylation of the EphRs, showing some preference for EphB4 followed by inhibition of EphB2, EphA2, EphB3 and EphA3.
NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration, inhibits VEGF driven tissue growth and angiogenesis in vivo.
M.Wt | 503.48 | |
Formula | C26H20F3N7O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Benzamide, 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]- |
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3. Wnuk M, et al. Kidney Int. 2012 Jun;81(12):1212-25.
4. Becerikli M, et al. Int J Cancer. 2015 Apr 15;136(8):1781-91.
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