Catalog No.: PC-21200Not For Human Use, Lab Use Only.
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively.
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively. NVP-HSP990 inhibits TRAP1 ATPase activity with IC50 of 320 nM, binds to the N-terminal ATP-binding domain of Hsp90. NVP-HSP990 does not show significant binding or functional activities against a panel of 83 diverse receptors/enzymes involved in major physiologic functions. NVP-HSP990 induces a signature response of Hsp90 inhibition and inhibits growth of a wide range of tumor cells. NVP-HSP990 (5 mg/kg twice weekly or 15 mg/kg weekly) demonstrates antitumor efficacy in the GTL-16 gastric cancer model.
